Get Megaloblastic Anemia Vs Iron Deficiency Anemia US. Megaloblastic anemia is a type of macrocytic anemia that results from inhibition of dna synthesis during red blood cell production. Bone marrow failure (e.g., due to myeloproliferative malignancy, myelodysplastic syndrome) can manifest with microcytic, normocytic, or macrocytic.
Microcytic anemia due to iron deficiency is the most common type of anemia in children.
The red cell distribution width (rdw) is high in iron deficiency anemia because there is a wide variation in red cell size. In addition, deficiencies of ascorbic acid, tocopherol and thiamine may be related to megaloblastic anemia. Megaloblastic anemia is caused when red blood cells aren't produced properly. When dna synthesis is impaired, the cell cycle cannot progress from the g2 growth stage to the mitosis (m) stage.
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