View Autoimmune Hemolytic Anemia Diagnosis UK . It should be part of the differential diagnosis for any normocytic or macrocytic anemia. Autoimmune hemolytic anemia is an uncommon group of disorders that can occur at any age. PPT - Left Upper Quadrant Pain and Masses PowerPoint ... from image.slideserve.com Hemolysis may occur intravascularly, extravascularly in the reticuloendothelial system, or both. Hemolytic anemia develops when there are not enough red blood cells because the body destroys them sooner than it should. Preclinical hematology and oncology pathology anemias normocytic anemia (increased hemolysis). These disorders affect women more often than men. The direct antiglobulin (direct coombs) test establishes the diagnosis and may suggest the cause. Paroxysmal nocturnal hemoglobinuria is a disorder characterized by a decrease of red blood cells (anemia). An autoimmune disor...